Acute nonlymphoblastic leukaemia in adults.

The epipodophyllotoxin VP16-213 in combination chemotherapy for adults with acute nonlymphoblastic leukaemia.

A total of 232 previously untreated adults with acute nonlymphoblastic leukaemia were consecutively entered into four successive studies. In the first, complete remission rates and survival were inferior to a group treated on the same regimen in London, suggesting population differences, possibly on the basis of late referral and poor nutritional status. In the second study the addition of the ...

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

An assessment of spatial clustering of leukaemias and lymphomas among young people in New Zealand.

STUDY OBJECTIVE To assess spatial clustering of childhood leukaemias and lymphomas in New Zealand, using a national dataset from a country with no nuclear installations. DESIGN New Zealand Map Grid coordinates, derived from the birth addresses of cases and controls were used in clustering analyses that applied Cuzick and Edwards' method. SETTING The whole of New Zealand. PARTICIPANTS The ...

Expression Profiling of Microarray Gene Signatures in Acute and Chronic Myeloid Leukaemia in Human Bone Marrow

Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute m...

A Review on Acute Lymphoblastic Leukaemia

Introduction he leukaemias are malignant neoplasms of the haemopoietic stem cells. 1 acute leukaemia is the most common malignancy in children. 2 In the United States the incidence of ALL is roughly 6000 new cases per year (as of 2009), or approximately 1 in 50,000. 3 Acute lymphoblastic leukaemia makes up three quarters of all cases of leukaemia in children and 20% of all cases of leukaemia in...